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At 1 h after administration, [ 3 H]proline accounted for 86.65% of the plasma radioactive components

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Pooled analyses of 199 placebo-controlled clinical studies (monotherapy and adjunctive therapy, median treatment duration 12 weeks) of 11 different AEDs across several indications showed that patients randomized to one of the AEDs had approximately twice the risk (adjusted Relative Risk 1.8, 95% CI 1.2, 2.7) of suicidal thinking or behavior compared to patients randomized to placebo

All participants provided written informed consent and were cleared for participation by passing a mandatory medical screening