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N Engl J Med 373:1122 Wadden TA, Foreyt JP, Foster GD et al (2011) Weight loss with Naltrexone sr/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial

Thyroid cancer The prescribing information for GLP-1RA lists MTC as a contraindication, based on a preclinical rodent study demonstrating that GLP-1R activation elevates cAMP levels in rodent thyroid C-cells, stimulates calcitonin release, and promotes C-cell hyperplasia and MTC development (200)

Most insurance companies respond to prior authorization requests within 35 business days, though some take up to 14 days

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The result is nausea, bloating, and in some cases vomiting