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Sun et al., in their study, identified the key role of Kla in the immunosuppressive microenvironment and treatment resistance of pancreatic ductal adenocarcinoma (PDAC), where high levels of Kla in PDAC are associated with an immunosuppressive TME, resulting in a reduction in CTLs (96)

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Minj E, Yadav RK, Mehan S (2021) Targeting abnormal Nrf2/HO-1 signaling in amyotrophic lateral sclerosis: current Insights on drug targets and influences on neurological disorders