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Neurodegenerative diseases Similar to muscle diseases, neurodegenerative conditions present altered mitochondrial homeostasis and NAD + metabolism, which have been thoroughly investigated as targets for NAD + modulation-based approaches 13,268,269

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[DOI] [PMC free article] [PubMed] [Google Scholar] Tramutola A, Triplett JC, Di Domenico F, Niedowicz DM, Murphy MP, Coccia R, Perluigi M, Butterfield DA