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Specifically, the cases ( n = 41) with a cardiac adverse event (Figure 3) were as follows: 17 (41.5%) arrhythmias, 3 (7.3%) deaths, 6 (14.7%) resuscitated cardiac arrests, 1 (2.4%) aneurysm, 5 (12.2%) arterial dissections (aortic or coronary), 2 (4.9%) cardiomyopathies, 5 (12.2%) cases of acute coronary syndrome, 1 (2.4%) case of hypertension, and 1 (2.4%) case of syncope

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Early-stage phenotypic screening data, target engagement biomarker data, or mechanistic rationale from a novel biological pathway all strengthen the non-obviousness argument

Lower doses are generally well-tolerated

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