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One GLP-1-based medication is not technically a stack
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N Engl J Med (2023)
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The use of parenteral MTX has gained popularity recently and is more beneficial than taking it orally, especially when administered subcutaneously (SC)
This table from the National Kidney Foundation shows how they can both be considered: They found that while there was a short drop (eGFR got worse) in the semaglutide group at treatment onset, it came back up and no difference in Cr-eGFR between the semaglutide and placebo groups was observed at week 24. In terms of body weight they found that No correlations were observed between changes in body weight and eGFR during 24-week treatment with semaglutide regardless of whether eGFR was estimated with creatinine or cystatin C or measured with iohexol clearance. They go on to point out that this is a consistent finding in trials of GLP-1 drugs and eGFR
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