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References: The glutathione system and the related thiol network in Caenorhabditis elegans

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It typically peaks during dose escalation and resolves within 1-2 weeks at each new dose level

The principle lipase implicated in TBI is cytoplasmic phospholipase A2 (cPLA2), which is upregulated after in vivo and in vitro experimental TBI and preferentially cleaves arachidonic acid as an essential part of enzymatic lipid peroxidation and inflammatory signal transduction [82]

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