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Regular liver function tests are recommended during treatment.Cardiovascular Risks: It can affect cholesterol levels (increasing LDL and decreasing HDL), which may raise the risk of atherosclerosis and coronary artery disease

As a water-soluble vitamin, excess B12 is typically excreted in urine rather than accumulating to toxic levels

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In diet-induced obesity (DIO) models, NNMT loss-of-function and selective small-molecule inhibitors reduce white adipose mass and improve metabolic parameters without overt toxicity, positioning NNMT as a tractable target for metabolic-disease research [24]