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This washout period is crucial for allowing insulin sensitivity and other biomarkers to fully normalize, preventing any cumulative negative effects

It is supplied to the laboratory and academic market as a research-use-only reference compound

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214 Therefore, to achieve large-scale clinical application, NADs must ensure easy production, quality control, and transportation

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Because the CH amino group is more active than its hydroxyl group, the process of acylation reaction preferentially favors the amino group (Kurita et al., 2002