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Anti-obesity drug therapy can be offered as an adjunct to a reduced-calorie diet and increased physical activity for weight management in adult patients with an initial body mass index (BMI) of 30 kg/m 2 or 2730 kg/m 2 in the presence of at least one weight-related comorbidity, e.g., dysglycemia, hypertension, dyslipidemia, or obstructive sleep apnea

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Collectively, metabolomics and proteomics confirmed that dual SHP2/MEK inhibition affects proliferation-related pathways, mitochondrial dynamics, and ferroptosis regulation

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