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Dose Requirements and Consistency: Because of first-pass metabolism and enzymatic breakdown, oral forms may require higher nominal dosing or specialized carriers to approach comparable exposure to injectables

The temperature sensitivity of tirzepatide means that prolonged exposure to room temperature reduces potency faster than most people expect

Moreover, accumulating evidence suggests that mitochondrial dysfunction, oxidative stress, and impaired protein quality control contribute to dopaminergic cell death in PD [12, 13]

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