glp-1 liver toxicity Pioglitazone with SGLT2 inhibitors or receptor agonists in patients with type 2 diabetes and non-alcoholic fatty disease: could the combinations of an old friend with new players yield better outcomes? Revolutionizing MASLD treatment with GLP-1

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Over time, natural rewards become less satisfying while the drug becomes increasingly important for maintaining motivation and pleasure

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Dose-response analysis indicates optimal benefits occur after approximately 50 weeks of continuous supplementation, suggesting long-term metabolic remodeling rather than acute effects