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Additionally, abolishment of myocardial protection by the PI3 K inhibitor LY294002 and by the p44/42 mitogen-activated protein kinase inhibitor UO126 implicates that both of this prosurvival pathways take part in cardioprotection mediated by GLP-1

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The Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) is a study comparing sitagliptin with placebo in diabetic patients with a previous history of cardiovascular disease