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128 Additionally, thalidomide inhibits M1 macrophage polarization by targeting the transcription factor IRF5, reduces the release of inflammatory signals, significantly reduces the secretion of the proinflammatory cytokines IL-12 and IFN-, and promotes intestinal mucosal healing

This side effect is almost always related to overuse rather than the ingredient itself

doi: 10.1016/j.dld.2009.08.002

[DOI] [PubMed] [Google Scholar] Soltwisch J., Kettling H., Vens-Cappell S., Wiegelmann M., Muthing J., Dreisewerd K

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