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Interestingly, it may be that these findings are showing that the minimal effective drug concentration very rapidly reaches the brain (i.e., at 1 min), because there is no change in time and dose-concentration

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If you increase your dose to get results, you are also increasing your exposure to potentially impure substances

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They also may help patients who reach a plateau in improvement using another therapy

Starting too high Enthusiasm leads many users to begin at doses higher than recommended