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Structurally, BPC-157 is a pentadecapeptide composed of fifteen amino acids derived from a partial gastric protein sequence

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These results delineate a PDHA1acetyl-CoAH3K27acSLC7A11/GSH axis that integrates metabolism, epigenetics, and cuproptosis regulation, and they support a therapeutic rationale for targeting PDHA1 to reactivate cuproptosis and overcome Enz resistance in CRPC

Generation of ribose-5-phosphate by the oxPPP will result in UMP m+1 labelling, whereas metabolization by the non-oxPPP will produce UMP m+2 labelling (Extended Data Fig

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