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Its ability to scavenge reactive oxygen species (ROS) is especially critical given the CNSs high metabolic activity and inherent susceptibility to oxidative stress-induced cellular injury

Tertiary Lymphoid Structures Represented a Unique Microenvironment with High Oxidative Stress We further investigated the redox status of TLS by immunostaining for two established markers of oxidative stress: 8-hydroxy-2-deoxyguanosine (8-OHdG) and 4-hydroxynonenal (4-HNE)

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Antonoff MB, Ragalie W, Correa AM, Spicer JD, Sepesi B, Roth JA, Walsh GL, WlL H, Swisher SG , Rice DC, Vaporciyan AA, Mehran RJ

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Adotvi O, Vernerey D, Jacoulet P, Meurisse A, Laheurte C, Almotlak H, Jacquin M, Kaulek V, Boullerot L et al (2023) Safety, immunogenicity, and 1-year efficacy of universal cancer peptide-based vaccine in patients with refractory advanced non-small-cell lung cancer: a phase Ib/phase IIa de-escalation study