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Hernandez AF, Green JB, Janmohamed S, DAgostino RB, Granger CB, Jones NP, et al

Meet our doctors Last reviewed: 27 Jan 2026 Sources Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review, Karger [accessed 18 December 2025] Physical discomfort due to redundant skin in post-bariatric surgery patients, Journal of Plastic, Reconstructive & Aesthetic Surgery [accessed 18 December 2025] Tummy tuck (abdominoplasty), NHS [accessed 18 December 2025] Aspects of excess skin in obesity, after weight loss, after body contouring surgery and in a reference population, Surgery for Obesity and Related Diseases [accessed 18 December 2025] Effects of once-weekly semaglutide on appetite, energy intake, control of eating, food preference and body weight in subjects with obesity, Diabetes, Obesity and Metabolism [accessed 18 December 2025] Weight loss injections NHS weight loss injections GLP-1 for weight loss Can doctors help with weight loss

Human trials testing DSIP for various applications used doses ranging from 25100 nmol/kg intravenously, with no doses exceeding 21.4 mcg/kg daily

GLP-1 receptor agonists slow gastric emptying and suppress appetite, which can reduce energy intake and cause fatigue Fatigue is most common during initial weeks and dose increases, often improving as the body adapts over several weeks to months Nutritional deficiencies in protein, iron, vitamin D, and B vitamins may develop when food intake drops significantly Optimising nutrition with nutrient-dense foods, maintaining hydration, and gentle physical activity can significantly reduce tiredness Contact your GP if fatigue is severe, worsening, or accompanied by signs of dehydration, hypoglycaemia, or persistent gastrointestinal symptoms Table of Contents Why GLP-1 Medications Can Cause Tiredness Glucagon-like peptide-1 (GLP-1) receptor agonists are increasingly prescribed medications for type 2 diabetes and weight management, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda)

doi: 10.3389/fonc.2020.00188 25 MoeiniPNiedwiedzka-RystwejP

Usage Cited in: Biomed Pharmacother