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It also acts through a receptor-independent pathway: direct suppression of NF-B nuclear translocation

Maintenance phase costs less because the per-dose volume holds while frequency drops

Further inquiries can be directed to the corresponding author and will be available at Zenodo.org

Marubayashi A, Nakaya Y, Fukui K, Li M, Arase S

When GHRH-R and GHSR-1a are activated simultaneously, GH pulse amplitude exceeds what either compound produces alone

Again, comparing the experimental data to the pHp model using the same derived pKa of 6.78, for the fit a value of S o is used to fit the data that is again consistently low, 0.35uM