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In the Steimle study, the authors demonstrated the impact of ZIP8 and ZIP14 knockdown on Mn transport across the BBB by loading 54 Mn into either the apical or basolateral side of transwells (Steimle et al., 2019)

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These cardioprotective effects may be attributed to improved blood sugar control, weight loss, reduced inflammation, and direct effects on blood vessels and the heart

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