Most side effects are gastrointestinal and occur during the initial weeks of treatment or when increasing the dose
Black Americans have an increased rate of angiotensin converting enzyme inhibitor-associated angioedema
Concerns about lean mass loss and metabolism Clinical data shows semaglutide can reduce lean body mass, with losses ranging from nearly 0% to 40% of total weight reduction
Padamsey, Z., Katsanevaki, D., Dupuy, N
Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus
Findings: RCTSURMOUNT-MAINTAIN - Tirzepatide for Maintenance of Bodyweight Reduction in Obesity, Lancet (2026) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=378 | length = 112 weeks) in adults with obesity who completed 60 weeks of open-label tirzepatide at the maximum tolerated dose (10 or 15 mg once weekly) Treatment: Continue tirzepatide maximum tolerated dose (MTD