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GHK appears to directly target myofibroblasts, converting pathological persistent collagen deposition to physiological collagen contraction through ITG-1 activation and apoptotic elimination of excess myofibroblasts (Figure 5)

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Statistical significance was assessed by an unpaired two-tailed t-test in a - i , l - n , and by Ordinary One-Way ANOVA followed by Dunnetts multiple comparisons test in j , k

10.1038/s41416-019-0637-9 252 ZhaoL.RaoX.ZhengR.HuangC.KongR.YuX.et al (2023)