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Importantly, reporting nausea and stopping treatment because of it are very different only about 4.3% discontinued for GI reasons in the STEP trials
In the 2022 SURMOUNT-1 study published in NEJM, three doses of tirzepatide were compared with placebo (1:1:1:1) to determine effects on percent weight change over the course of 72 weeks
Additionally, GLP-1 reduces the release of glucagon, another hormone produced by the pancreas, which typically signals the liver to release stored glucose
This research theorized that hyperglycemia can lead to a downregulation of GIPr causing decreased GIP response despite therapeutic or even supratherapeutic levels of GIP [21]
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In case you dont already know: GLP-1s are a class of hormone-mimicking drugs that bind to a receptor in the body in order to delay gastric emptying, make you feel fuller for longer, and lower blood sugar
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