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Mass spectrometry analysis of UNC119B adducts after Lys-C digestion Samples of UNC119B (200 g protein per sample), either treated with compound 7 or vehicle DMSO, were processed by denaturation, reduction, alkylation, and digestion with rLys-C (Promega V1671), followed by desalting prior to mass spectrometry analysis

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One significant concern is the potential for treatment discontinuation due to cost, drug shortage, or adverse effects, which can lead to a deterioration in key cardiometabolic parameters, including glycemic control, blood pressure, and cholesterol levels

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