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Enhanced expression of growth hormone receptors in tendon fibroblasts has been observed, which may facilitate cell proliferation and matrix synthesis in regenerating tissues (1)

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The peptide also promotes polarization of macrophages from pro-inflammatory M1 phenotypes toward tissue-repairing M2 phenotypes, with treated macrophages showing 70% increased phagocytic activity for clearing inflammatory debris and 3-fold higher production of VEGF compared to untreated controls

1H-NMR aromatic region assignment

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Some peptides influence growth hormone release rather than supplying hormones externally