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36,37 Findings from other research studies have contradicted this proposition, however, showing that the association between hyperphosphatemia and liver failure is only evident in patients with acute renal failure (with 5080% of patients with acute liver failure having concomitant acute renal failure 38 )

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some conclusions on platinum accumulation and long-term complications are only based on observational cohort data, with unadjusted confounding factors, leaving the causal evidence chain to be further improved