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Methanolic leaf extracts of Hawaiian kava cultivars showed stronger binding inhibition to several CNS receptorsincluding GABA A , dopamine D2, opioid (, ), and histamine (H1, H2)than root extracts, suggesting that compounds beyond the main kavalactones may contribute to the pharmacological effects of kava leaves
Zehetner explains: These side effects result from delayed gastric emptying and altered intestinal motility triggered by the medications
2005, Sigman et al
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