The tissue-specific effect of l-carnitine was found in many experiments in mammals or fish, in which the carnitine content of muscle was relatively stable, whereas the liver was more sensitive to carnitine supplementation or deficiency ( Reference Li, Li and Qin 32 , Reference Morand, Bouitbir and Felser 48 , Reference Wchter, Vogt and Kreis 49 )
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A phase II, open-label clinical trial evaluating the effect of combined thiamin-biotin supplementation, at moderate (600 mg/day of thiamin and 150 mg/day of biotin) and high (1,200 mg/day of thiamin and 300 mg/day of biotin) dosages, in Huntingtons disease is currently underway (75)
doi: 10.1016/j.neucli.2020.07.002, 196 StrazzaP
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