For the first week or two, tirzepatide is still providing most of the GLP-1 receptor activation
however, these GLP-1 receptor agonists induce growth hormone secretion which stimulates the livers production of insulin-like growth factor-1 (IGF-1), which may be a cause of acne vulgaris development via sebum production
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If these effects impact your daily life, try adopting lifestyle changes to help you return to your normal routines