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this phenomenon has been linked with the increased resistance at doxorubicin treatment due to the lack of CT2 in the cell membrane that, in turn, impairs drug entry into cancer cells (Novak et al., 2015)

Short-term isotretinoin treatment decreases insulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels: does isotretinoin affect growth hormone physiology

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Only three cytokine like proteins termed unpaired (upd), upd2, and upd3 are recognized as JAK-STAT pathway ligands in Drosophila (144)

Westphal LM, Polan ML, Trant AS, Mooney SB