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Taken over several days, as little as 25 percent above the maximum daily dose or just two additional extra strength pills a day has been reported to cause liver damage, according to the agency

They may have the potential to cause bone loss

Singh HB

L-citrulline raises plasma arginine levels roughly twice as effectively as an equal dose of L-arginine, because it bypasses the gut and liver enzymes that degrade up to 50% of oral arginine

The tolerable upper limit for children, ages 9-13, is 280 mcg

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