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The SURPASS-5 study evaluated the efficacy and safety of an injectable mixture therapy: TZP and insulin glargine

plus secondary sources on GLP-1 adverse effect profiles, contraindication guidance (FDA prescribing information for Ozempic, Wegovy, Mounjaro), and post-discontinuation weight regain data

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To control for the confounding effect of body weight, an Analysis of Covariance (ANCOVA) was performed on key variables, with the final body weight entered as a covariate

Electrolyte supplementation becomes more important with heavy sweating combined with the dehydration risks of semaglutide