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Intravenous ifosfamide/mesna is associated with depletion of plasma thiols without depletion of leukocyte glutathione

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Keep a symptom diary documenting when tiredness occurs, its severity, and any associated factors (meals, medication timing, activities)

That approach works until subtle hunger cues disappear and hydration and nutrient intake fragment, which can lead to weakness, nutrient gaps, and avoidable side effects

Realistic expectations matter when your baseline diet is adequate

A widely accepted view is that many unfavorable conditions result in the appearance of reactive oxygen species (ROS) (Pitzschke et al., 2 O 2 , having an intrinsic reactivity with the organic molecules which can be consequently either damaged or undergo a redox modification