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Some patients experience laryngopharyngeal symptoms such as a chronic cough, hoarseness, or a sensation of a lump in the throat which may be associated with reflux, though the relationship is not always straightforward and requires clinical assessment

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Laboratorybased changes: Mild elevations in liver enzymes, triglycerides, and total cholesterol are common during isotretinoin therapy, often detected through routine laboratory tests and monitored with serial measurements to guide doseadjustment or interruption