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Lpez-Otn et al., 2013 Restoring NAD+ levels has been demonstrated to reverse measurable aspects of mitochondrial dysfunction, improve muscle insulin sensitivity, enhance cognitive function, and reduce systemic inflammation in clinical populations
The effects of metformin on the gut microbiota of patients with type 2 diabetes: a two-center, quasi-experimental study
In colorectal cancer cell lines (HT-29 and SW620), knockdown of IGF-1R by small interfering RNA resulted in a blockade of the downstream PI3K/Akt and typical Wnt signaling pathways, which ultimately inhibited cancer cell proliferation and promoted apoptosis (103)