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The suppression of K63-ubiquitination of KEAP1 is mediated by OTU deubiquitinase 1 (OTUD1), which may inhibit ROS-induced oxeiptosis in kidney cancer cells [161]

336 In addition, miR-145 regulates the expression of the drug resistance gene MDR1, thereby improving drug sensitivity to 5-aminosalicylic acid and glucocorticoids in the treatment of UC

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