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The overall clinical significance is limited

We excluded studies that were (i) conducted on animals, (ii) unpublished, or (iii) written in languages other than English

References Awwad, S., Issa, R., Alnsour, L., Albals, D., & Al-Momani, I

The 5,10-methylene dehydrogenase activity of the MTHFD1 encoded enzyme converts 5,10-methylene-THF to 5,10-methenyl-THF

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