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For midlife women, the metabolic framework can be understood as a four-phase sequence

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Ceramides can also be glucosylated by glucosylceramide synthase (GCS) forming glucosylceramides which then serve as the building blocks of complex glycosphingolipids

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Halo nevi have the dermoscopic features of benign MNs, with globular and/or homogeneous patterns that are typically observed in children and young adults