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The most significant clinical evidence for retatrutide to date comes from a Phase 2 trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023)

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Bland foods such as crackers, toast, or rice may be better tolerated during symptomatic periods

Ultimately, it was revealed that cholinergic fibers are present within the subchondral bone of individuals with OA, and the release of acetylcholine (Ach) triggered by vagus nerve stimulation plays a prominent role in combating inflammation across various diseases while also providing pain relief

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