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How does the methylation process work

Clinical trials have studied continuous use up to 24 weeks with sustained benefits

Step 3: Prescription & Fulfillment If approved, your prescription is sent to a licensed pharmacy for compounding and shipped directly to your address

Metabolism plays a pivotal role in the aging process, and disruptions in metabolic pathways are often associated with age-related diseases

Active B12: Each capsule provides 1 mg vitamin B12 as methylcobalamin, which is more efficiently used by the body compared to other forms of vitamin B12, like cyanocobalamin Heart & Brain Health: Supports a normal level of homocysteine in the body to benefit healthy cardiac function, blood cell formation, and optimal nerve function* Sleep Support: Helps maintain normal circadian rhythms to support restful sleep and supports healthy methylation processes in the body* Third-Party Certified: This product has been third-party tested and certified to verify what's in the package matches what's on the label and to confirm it contains no unsafe levels of contaminants Trusted: Thorne is trusted by 100+ professional sports teams and the #1 most recommended clinical brand by consumers and health-care practitioners (Based on a 2026 independent survey of US supplement consumers and health-care practitioners)