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The neuropathological changes of AD brain, based on brain imaging studies, show slow and progressive cerebral atrophy, where the frontal and temporal cortices often have enlarged sulcal spaces with atrophy of the gyri, while primary motor and somatosensory cortices most often appear unaffected (Perl, 2010)

Research protocols have used multiple administration routes, including intraperitoneal, subcutaneous, intramuscular, intravenous, and oral delivery , strictly within preclinical research settings

[19] [20] An initial intensive treatment phase (e.g., daily IV therapy for several weeks) is sometimes followed by an oral maintenance dose in longer-term management, based on German clinical protocols for neuropathy

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