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Decreased mRNA expression or protein levels for TGF1, TGFBR1 [41], SMAD3 [42], SMAD6 [43], and SMAD7 [41, 43] have been reported in more advanced stages of COPD or fibroblasts from COPD patients

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[6] While cosmetic use differs from wound care applications, the underlying repair-oriented activity helps explain why GHK-Cu is often used to support overall skin rejuvenation