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*Correspondence: Renjun Gu, [email protected]

Therefore, we were able to estimate the sample size required to accept or reject a minimal difference between GLP-1 agonists and control 18,19

Common Areas Affected After GLP-1 Weight Loss After major weight reduction, certain areas tend to show the most visible changes

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These include: Nausea (affecting up to 43% of patients at weight management doses) Vomiting (up to 23%) Diarrhoea (up to 30%) Constipation (up to 24%) Abdominal pain or discomfort These effects typically diminish over time as the body adapts, though some patients experience persistent symptoms requiring dose adjustment or discontinuation