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However, most studies examining the effect of dietary LC on ER stress were relative to reducing apoptosis, oxidative stress and myocardial damage (Reference Gao, Li and Zhu11,Reference Kong, Zheng and Liu13Reference Zhang, Wu and Shen15)

This dual glucose-dependent insulinotropic capability means that Tirzepatide can more comprehensively address the complex interplay of hormones that regulate blood sugar levels

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The mechanisms underlying the development of DN remain unknown but long-standing hyperglycemia is the main key factor because of the metabolic alterations it induces, such as increased polyol flux, which leads to accumulation of advanced glycation end products, oxidative stress, and lipid disorders

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