Yoo, Jin S., Yasunori Yoshimoto, Rebecca P
*Correspondence: Lin Wang, [email protected] This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Glutathione is the bodys primary antioxidant
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The unfolded protein response (UPR) marker protein kinase RNA-like ER kinase (PERK), as a key sensor in the UPR, is activated when endoplasmic reticulum stress occurs and phosphorylates its downstream transcription factor ATF4, ATF4 directly binds upstream of the xCT promoter and promotes its transcription, ensuring sufficient cystine uptake and maintaining intracellular redox homeostasis