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Anionic surfactants commonly used in shampoos can sometimes interfere with peptide stability, making it essential to conduct stability testing under various storage conditions and pH ranges

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It would not be feasible to remove these from the diet altogether, such as glycerol 274 , amino acids that lead to acetate production through proteolytic fermentation by gut bacteria 275 , or by the degradation of mucins and other glycoproteins that are secreted by the gut lining 276

Acknowledging and accounting for these determinants is the cornerstone of translating SFNs promise into predictable and potent clinical outcomes