Risks and Safety Considerations to Discuss With Your Doctor Combined use may compound individual risks including unpredictable glycaemic fluctuations, fluid retention, nausea, gallbladder complications, and pancreatitis
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According to the American Diabetes Association , studies comparing GLP-1 medications have demonstrated significant weight loss potential for both semaglutide and tirzepatide
8 Additionally, a small number of animal and clinical trials have highlighted the benefits of individual GLP-1 RAs, including exenatide and lixisenatide
Clinical trials did not control for injection time because it does not significantly affect the drug is efficacy