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It has to be considered, though, that the bioavailability of fisetin after oral administration is poor, so it is necessary to develop an effective delivery method to enhance its therapeutic potential in treatment of a particular disease, e.g

By that, it's meant that once the RING finger E3 ligase binds with the E2 containing the ubiquitin, it simply acts as a targeting device which directs the E2 to directly ligate the target protein at the lysine site

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2022 [cited 2022 Jun 15]

It will be run at multiple Korean hospitals as a randomized, double-blind, placebo-controlled study

1 Introduction Weight management and improvement in overall health are fundamental goals in treating obesity