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Early amylin analog development was marked by pramlintide's modest clinical impact (~23% weight loss) and poor adherence due to three-times-daily dosing

Dose titration, side effect management, and treatment review are part of responsible prescribing

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K , L Shown are representative HE stains and PAS stain

A previous report used incubated HeLa cells with a range of aspirin concentrations from 0.5 to 20 mM to generate aspirin-mediated and non-specific acetylation of many cellular proteins, including TrxR1 (Tatham et al., 2017)