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aspirin*, ibuprofen, naproxen), PPIs (omeprazole, pantoprazole), diuretics (loop diuretics, thiazides), probenecid, antibiotics (penicillins, sulfonamides, ciprofloxacin, cefalotin), cisplatin, and antiseizure medications (levetiracetam, phenytoin and sodium valproate) can reduce methotrexate clearance

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Furthermore, with the results of the isobologram and combination index analysis, the synergistic effects were also evaluated showing nystose and panose combinations having the greatest synergistic effects (114)